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when my mice breed i always leave the nest as it is, and disturb the nest as little as possible, in the few hours after they are born i will check the nest and remove any dead or malformed mice, and then leave the mum to it. I'll clean the rest of the tank out just as i would without the babies in there, but leave the nest as it is until the babies leave it of their own accord. the mum does a great job of keeping the nest clean and keeping the babies clean too.
 
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