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Handling T's is a general no-no.

If you HAVE to handle them, then a Red-Knee is one of the 'safer' ones

Why the big nono?
I only agree that you really shouldnt contemplate handling IF you put either your own or the spiders life in jepoardy

If done correctly what detrimental affects are there?
My spiders still eat, they still molt, they still breed. what more can you ask?

As far as i can see, there is nothing whoelly wrong and bad about holding spides.
Most people tell you 'NO!!!!' because they themselves are too afriad of the consequences....
but... consequences being? ...
Those that arent sacared generally say that they dont, or its not recommended... fair enough, it isnt recommended for all.
Iv held Brachypelma, Grammastola, Aphonopelma, Chromatopelma, Theraphosa, Lasiodora, Poecilotheria, Cyriopagopus, Selenocosmia, even macrothele (funnelweb)... never been bitten, never had an aggresive reaction.
Iv had my GBB pull its fangs out and walk them against the palm of my hand whilsit suspended upside down, for added grip, at no point did it decide to try out the new 'substrate' for flavour, lol
If you take even the most possessed spawn of eight legged satan out of its own environment and the personality changes
You just need to appreciate that the spider will take a much longer time working out if your a threat or not.
They are stimulus based, you give them something to react to and they will.
If they feel comfrotable on you, then you dont have a problem.
I have endured some pretty painful things becuase i have had to to avoid a bigger problem, such as having a constant dripping of boiling water on my naked arm whilst carrying a leaking pot in a kitchen for bowt a minute, lol
If you can be confident in your reaction to a bite, and your not scacred of it, then wahts the beef?
Spiders arent incredibly primitve, they have basic learning ability. Try handling a WC OBT compared to a CB one, or even a CB one that is familiar with the scentof flesh. They do react different than if they hadnt everr touched human flesh, they are calmer
they understand threats and non-threats. If you dont pose yourself as a threat then they dont need to react.

As Becky said, Brachys thend to be flicky. Iv yet to have one flick hairs at my when its being handled. The same spider will shower me with hair if i disturb it in its own environment tho

 

[C_Strike]

I will always touch the spiders leg with a brush or something first. But the main situation i hold them is when they are already on a little walking mission in the tank.
That is the only way i would and have hed my big buggers.
im not too fussed about touching the side of the spider with my finger if its Grammies/ brachys and other 'docile' temperment spiders still generally use a brush.